Network control through coordinated inhibition

Coordinated excitatory and inhibitory activity is required for proper brain functioning. Recent computational experimental studies have demonstrated that patterns in recurrent cortical networks are dominated by inhibition. Whereas previous suggested plasticity important homeostatic control, this new framework puts inhibition the driver’s seat. Complex neuronal comprise many configurations parallel, controlled external internal ‘switches’. Context-dependent modulation of connections play a key role memory learning. It therefore to realize synaptic often multisynaptic balance between excitation not fixed, but depends on context level.